Revealing G-protein-coupled receptor oligomerization at the single-molecule level through a nanoscopic lens: methods, dynamics and biological function.

@article{Scarselli2016RevealingGR,
  title={Revealing G-protein-coupled receptor oligomerization at the single-molecule level through a nanoscopic lens: methods, dynamics and biological function.},
  author={Marco Scarselli and Paolo Annibale and Peter J McCormick and Shivakumar Kolachalam and Stefano Aringhieri and Aleksandra Radenovic and G. Corsini and Roberto Maggio},
  journal={The FEBS journal},
  year={2016},
  volume={283 7},
  pages={
          1197-217
        }
}
The introduction of super-resolution fluorescence microscopy has allowed the visualization of single proteins in their biological environment. Recently, these techniques have been applied to determine the organization of class A G-protein-coupled receptors (GPCRs), and to determine whether they exist as monomers, dimers and/or higher-order oligomers. On this subject, this review highlights recent evidence from photoactivated localization microscopy (PALM), which allows the visualization of… CONTINUE READING

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 20 CITATIONS

G-Protein-Coupled Receptor Dimers

VIEW 10 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED