Revascularization of ischemic limbs after transplantation of human bone marrow cells with high aldehyde dehydrogenase activity.

@article{Capoccia2009RevascularizationOI,
  title={Revascularization of ischemic limbs after transplantation of human bone marrow cells with high aldehyde dehydrogenase activity.},
  author={Benjamin J. Capoccia and Debra L. Robson and Krysta D Levac and Dustin J Maxwell and Sarah A. Hohm and Marian J Neelamkavil and Gillian I. Bell and Anargyros Xenocostas and Daniel C. Link and David R. Piwnica-Worms and Jan A Nolta and David A Hess},
  journal={Blood},
  year={2009},
  volume={113 21},
  pages={5340-51}
}
The development of cell therapies to treat peripheral vascular disease has proven difficult because of the contribution of multiple cell types that coordinate revascularization. We characterized the vascular regenerative potential of transplanted human bone marrow (BM) cells purified by high aldehyde dehydrogenase (ALDH(hi)) activity, a progenitor cell function conserved between several lineages. BM ALDH(hi) cells were enriched for myelo-erythroid progenitors that produced multipotent… CONTINUE READING
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Functional characterization of highly purified human 5350

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