Return of the lysergamides. Part VI: Analytical and behavioural characterization of 1-cyclopropanoyl-d-lysergic acid diethylamide (1CP-LSD).

@article{Brandt2020ReturnOT,
  title={Return of the lysergamides. Part VI: Analytical and behavioural characterization of 1-cyclopropanoyl-d-lysergic acid diethylamide (1CP-LSD).},
  author={Simon D Brandt and Pierce V Kavanagh and Folker Westphal and Alexander Stratford and Anna U Odland and Adam K. Klein and Geraldine Dowling and Nicola M. Dempster and Jason Wallach and Torsten Passie and Adam L. Halberstadt},
  journal={Drug testing and analysis},
  year={2020}
}
Lysergic acid diethylamide (LSD) is a prototypical serotonergic psychedelic drug and the subject of many clinical investigations. In recent years, a range of lysergamides has emerged with the production of some being inspired by the existing scientific literature. Others, for example various 1-acyl substituted lysergamides, did not exist before their appearance as research chemicals. 1-Cylopropanoyl-LSD (1CP-LSD) has recently emerged as a new addition to the group of lysergamide-based designer… 
Analytical profile of N-ethyl-N-cyclopropyl lysergamide (ECPLA), an isomer of lysergic acid 2,4-dimethylazetidide (LSZ).
TLDR
Key analytical data that can be used to detect ECPLA are required for future forensic and clinical investigations, and ECPLA and LSZ could be differentiated by NMR, GC-sIR, GC, and LC-based methods.
The use patterns of novel psychedelics: experiential fingerprints of substituted phenethylamines, tryptamines and lysergamides.
TLDR
NP classes may hold distinct AE rates and phenomenology, the latter potentially clouded by the subjective nature of these experiences, and further targeted research is warranted.
1H Nuclear Magnetic Resonance: A Future Approach to the Metabolic Profiling of Psychedelics in Human Biofluids?
TLDR
It is found that the most current use of 1H NMR in psychedelic research has been for the structural elucidation and analytical characterisation of psychedelic molecules and that no papers used 1HNMR in the metabolic profiling of biofluids, thus exposing a current research gap and the underuse of 1h NMR.

References

SHOWING 1-10 OF 30 REFERENCES
Return of the lysergamides. Part V: Analytical and behavioural characterization of 1-butanoyl-d-lysergic acid diethylamide (1B-LSD).
TLDR
This study presents a comprehensive analytical characterization of 1B-LSD employing nuclear magnetic resonance spectroscopy (NMR), low- and high-resolution mass spectrometry platforms, gas- and liquid chromatography (GC and LC), and GC-condensed phase and attenuated total reflection infrared spectroscopic analyses, which suggest that the behavioral effects of1B- LSD are reminiscent of LSD and other serotonergic hallucinogens.
Return of the lysergamides. Part I: Analytical and behavioural characterization of 1-propionyl-d-lysergic acid diethylamide (1P-LSD).
TLDR
It is found that 1P-LSD produced a dose-dependent increase in HTR counts, and that it had ~38% of the potency of LSD, consistent with its classification as a serotonergic hallucinogen.
Return of the lysergamides. Part IV: Analytical and pharmacological characterization of lysergic acid morpholide (LSM-775).
TLDR
Findings suggest that 5-HT1A activation by L SM-775 masks its ability to induce the head twitch response, which is potentially consistent with reports in the literature indicating that LSM-775 is only capable of producing weak LSD-like effects in humans.
Return of the lysergamides. Part III: Analytical characterization of N6 -ethyl-6-norlysergic acid diethylamide (ETH-LAD) and 1-propionyl ETH-LAD (1P-ETH-LAD).
TLDR
Two newly emerging lysergamides, namely N6 -ethyl-6-norlysergic acid diethylamide (ETH-LAD) and 1P-ETH- LAD, were characterized by gas chromatography-mass spectrometry, low and high mass accuracy electrospray MS(/MS), GC solid-state infrared analysis, high performance liquid chromatography diode array detection as well as nuclear magnetic resonance spectroscopy.
Return of the lysergamides. Part II: Analytical and behavioural characterization of N6 -allyl-6-norlysergic acid diethylamide (AL-LAD) and (2'S,4'S)-lysergic acid 2,4-dimethylazetidide (LSZ).
TLDR
Analytical characterization of powdered AL-LAD and LSZ tartrate samples and their semi-quantitative determination on blotter paper is reported to assist research communities that are interested in various aspects related to substance use and forensic identification.
Pharmacological characterization of the LSD analog N-ethyl-N-cyclopropyl lysergamide (ECPLA)
TLDR
These findings demonstrate that the pharmacological properties of ECPLA, MIPLA, and LAMPA are reminiscent of LSD and other lysergamide hallucinogens.
PHARMACOLOGY OF LYSERGIC ACID DIETHYLAMIDE AND SOME OF ITS RELATED COMPOUNDS
  • E. Rothlin
  • Chemistry, Medicine
    The Journal of pharmacy and pharmacology
  • 1957
TLDR
The scope of this review is limited to the main experimental results of the LSD problem and the contribution of the drug to the recent advances made in the study of psychogenic agents is assessed.
Identification of 1-Butyl-Lysergic Acid Diethylamide (1B-LSD) in Seized Blotter Paper Using an Integrated Workflow of Analytical Techniques and Chemo-Informatics
TLDR
The current work describes the application of such a workflow in the analysis of a single blotter paper, seized by Swedish customs, that led to the identification of a lysergic acid diethylamide (LSD) derivative, 1-butyl-lysergic acid dietsd (1B-LSD).
Dark Classics in Chemical Neuroscience: Lysergic Acid Diethylamide (LSD).
TLDR
It remains to be seen whether therapeutic value for LSD can be confirmed in controlled clinical trials, but promising results have been obtained in small pilot trials of depression, anxiety, and addictions using psilocybin, a related psychedelic molecule.
...
1
2
3
...