Retrovirus vector silencing is de novo methylase independent and marked by a repressive histone code.

Abstract

Retrovirus vectors are de novo methylated and transcriptionally silent in mammalian stem cells. Here, we identify epigenetic modifications that mark retrovirus-silenced transgenes. We show that murine stem cell virus (MSCV) and human immunodeficiency virus type 1 (HIV-1) vectors dominantly silence a linked locus control region (LCR) beta-globin reporter… (More)

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Cite this paper

@article{Pannell2000RetrovirusVS, title={Retrovirus vector silencing is de novo methylase independent and marked by a repressive histone code.}, author={Dylan Pannell and Caroline Osborne and S. Yao and Tatyana Sukonnik and Peter Pasceri and Angelo Karaiskakis and M. Motohiko Okano and Ellen Li and Howard D. Lipshitz and J. Ellis}, journal={The EMBO journal}, year={2000}, volume={19 21}, pages={5884-94} }