Retrovirus-mediated suicide gene/prodrug therapy targeting thyroid carcinoma using a thyroid-specific promoter.

@article{Braiden1998RetrovirusmediatedSG,
  title={Retrovirus-mediated suicide gene/prodrug therapy targeting thyroid carcinoma using a thyroid-specific promoter.},
  author={Vera Braiden and Yuji Nagayama and Makoto Iitaka and Hiroyuki Namba and Masami Niwa and Shunichi Yamashita},
  journal={Endocrinology},
  year={1998},
  volume={139 9},
  pages={3996-9}
}
To develop gene therapy targeting thyroid carcinoma, the recombinant retrovirus (LNTGTK) carrying herpes simplex virus thymidine kinase (HSV-TK) gene under the control of thyroglobulin (TG) promoter was constructed and its efficacy was investigated in 3 thyroid cell lines; a differentiated normal rat thyroid cell line (FRTL5), malignant rat thyroid carcinoma cells derived from FRTL5 (FRTC) and a human anaplastic thyroid carcinoma cell line (FRO). TG mRNA was detected by Northern blot analysis… CONTINUE READING
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