Retrovirus-mediated Gene Transfer of Rat Glutathione S-Transferase Yc Confers Alkylating Drug Resistance in NIH 3 T 3 Mouse Fibroblasta 1

@inproceedings{Greenbaum2006RetrovirusmediatedGT,
  title={Retrovirus-mediated Gene Transfer of Rat Glutathione S-Transferase Yc Confers Alkylating Drug Resistance in NIH 3 T 3 Mouse Fibroblasta 1},
  author={Mona Greenbaum and Sylvain and R J La and Homa Assar and Robyn L. Schecter and Leonel Gerald and Batist and Denis Cournoyer},
  year={2006}
}
A niii.jor limitation to successful cancer treatment is the existence of drug resistance. While several mechanisms of drug resistance have now been well characterized, mechanisms of resistance to alkylating drugs have remained less well defined. Several experimental models of alkylator resistance have implicated isoforms of glutathione S-transferase (GST… CONTINUE READING