Retrovirus-like Gag Protein Arc1 Binds RNA and Traffics across Synaptic Boutons

@article{Ashley2018RetroviruslikeGP,
  title={Retrovirus-like Gag Protein Arc1 Binds RNA and Traffics across Synaptic Boutons},
  author={James Ashley and Benjamin Cordy and Diandra Lucia and Lee G. Fradkin and Travis Thomson},
  journal={Cell},
  year={2018},
  volume={172},
  pages={262-274.e11}
}
Arc/Arg3.1 is required for synaptic plasticity and cognition, and mutations in this gene are linked to autism and schizophrenia. Arc bears a domain resembling retroviral/retrotransposon Gag-like proteins, which multimerize into a capsid that packages viral RNA. The significance of such a domain in a plasticity molecule is uncertain. Here, we report that the Drosophila Arc1 protein forms capsid-like structures that bind darc1 mRNA in neurons and is loaded into extracellular vesicles that are… CONTINUE READING

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