Retrovirally transduced antisense sequences stably suppress P210BCR-ABL expression and inhibit the proliferation of BCR/ABL-containing cell lines.

@article{Martiat1993RetrovirallyTA,
  title={Retrovirally transduced antisense sequences stably suppress P210BCR-ABL expression and inhibit the proliferation of BCR/ABL-containing cell lines.},
  author={Philippe Martiat and Philippe Lewalle and A S Taj and Magali Philippe and Y. Larondelle and J. L. Vaerman and Claude Wildmann and John M. Goldman and Jean Louis Michaux},
  journal={Blood},
  year={1993},
  volume={81 2},
  pages={502-9}
}
There is now strong evidence that the BCR-ABL gene product of the Philadelphia chromosome (P210) plays a crucial role in the pathogenesis of chronic myeloid leukemia (CML). We have previously shown that introduction of antisense oligonucleotides into K562 cells could transiently block the expression of P210 and specifically inhibit cellular growth in culture. In this report, we describe the use of a retroviral vector to introduce selected antisense and sense sequences, first into murine B10… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 19 references

Selective inhibition of leukemia cell proliferation by BCR-ABL antisense oligonucleotides

  • C Szczylik, T Sikorsky, +5 authors B Calabretta
  • Science 253:562,
  • 1991

Similar Papers

Loading similar papers…