Retroviral vectors bearing IgG-binding motifs for antibody-mediated targeting of vascular endothelial growth factor receptors.

@article{Masood2001RetroviralVB,
  title={Retroviral vectors bearing IgG-binding motifs for antibody-mediated targeting of vascular endothelial growth factor receptors.},
  author={Rizwan Ali Masood and Erlinda M. Gordon and M D Whitley and Beibei Wu and Patricia A. Cannon and Leah Evans and William F. Anderson and Parkash Gill and Frederick L. Hall},
  journal={International journal of molecular medicine},
  year={2001},
  volume={8 4},
  pages={
          335-43
        }
}
Targeting retroviral vectors to tumor vasculature is an important goal of cancer gene therapy. In this study, we report a novel targeting approach wherein IgG-binding peptides were inserted into the Moloney murine leukemia virus (MuLV) envelope (env) protein. The modifications on the viral env included replacement of the entire receptor binding region of the viral env with protein A (or ZZ) domains. The truncated env incorporating IgG-binding motifs (known as proteins) provided the targeting… CONTINUE READING

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