Retroviral transfer of the nlsLacZ gene into human CD34+ cell populations and into TF-1 cells: future prospects in gene therapy.

@article{Bagnis1994RetroviralTO,
  title={Retroviral transfer of the nlsLacZ gene into human CD34+ cell populations and into TF-1 cells: future prospects in gene therapy.},
  author={Claude Bagnis and Gw{\'e}naelle Gravis and A. M. Imbert and Daniel Herrera and T Allario and R. Galindo and Massimo Lopez and C Pav{\'o}n and Christine Semp{\'e}r{\'e} and Patrice Mannoni},
  journal={Human gene therapy},
  year={1994},
  volume={5 11},
  pages={1325-33}
}
Few data are available concerning behavior of reimplanted human hematopoietic cells after autologous stem cell transplantation. This paper reports the possibility to transfer gene markers coding for beta-galactosidase (beta-Gal) activity by retroviral vectors into a human leukemic growth factor-dependent cell line, TF-1, and into human hematopoietic progenitors isolated from peripheral blood or bone marrow. Using various combinations of retroviral vectors and packaging cell lines, we… CONTINUE READING

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