Retroviral transduction of IL2RG into CD34(+) cells from X-linked severe combined immunodeficiency patients permits human T- and B-cell development in sheep chimeras.

@article{Tsai2002RetroviralTO,
  title={Retroviral transduction of IL2RG into CD34(+) cells from X-linked severe combined immunodeficiency patients permits human T- and B-cell development in sheep chimeras.},
  author={Emily J. Tsai and Harry L Malech and Martha R. Kirby and Amy P. Hsu and Nancy E. Seidel and Christopher D. Porada and Esmail D. Zanjani and David M. Bodine and Jennifer M Puck},
  journal={Blood},
  year={2002},
  volume={100 1},
  pages={72-9}
}
X-linked severe combined immunodeficiency (XSCID) is caused by mutations of the common gamma chain of cytokine receptors, gamma(c). Because bone marrow transplantation (BMT) for XSCID does not provide complete immune reconstitution for many patients and because of the natural selective advantage conferred on lymphoid progenitors by the expression of normal gamma(c), XSCID is a good candidate disease for therapeutic retroviral gene transfer to hematopoietic stem cells. We studied XSCID patients… CONTINUE READING