Retroviral restriction factor TRIM5alpha is a trimer.

  title={Retroviral restriction factor TRIM5alpha is a trimer.},
  author={Claudia C Mische and Hassan Javanbakht and Byeongwoon Song and Felipe D{\'i}az-Griffero and Matthew H. Stremlau and Bettina Strack and Zhihai Si and Joseph Sodroski},
  journal={Journal of virology},
  volume={79 22},
The retrovirus restriction factor TRIM5alpha targets the viral capsid soon after entry. Here we show that the TRIM5alpha protein oligomerizes into trimers. The TRIM5alpha coiled-coil and B30.2(SPRY) domains make important contributions to the formation and/or stability of the trimers. A functionally defective TRIM5alpha mutant with the RING and B-box 2 domains deleted can form heterotrimers with wild-type TRIM5alpha, accounting for the observed dominant-negative activity of the mutant protein… CONTINUE READING

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