Retroviral oncogenes and TOR.

  title={Retroviral oncogenes and TOR.},
  author={Masahiro Aoki and Peter K. Vogt},
  journal={Current topics in microbiology and immunology},
Retroviruses have recruited the catalytic subunit of PI 3-kinase and its downstream target, Akt, as oncogenes. These viruses cause tumors in animals and induce oncogenic transformation in cell culture. The oncogenicity of these viruses is specifically inhibited by rapamycin; retroviruses carrying other oncogenes are insensitive to this macrolide antibiotic. Rapamycin is an inhibitor of the TOR (target of rapamycin) kinase whose downstream targets include p70 S6 kinase and the negative regulator… CONTINUE READING