Retroviral mutation rates and A-to-G hypermutations during different stages of retroviral replication.

@article{Kim1996RetroviralMR,
  title={Retroviral mutation rates and A-to-G hypermutations during different stages of retroviral replication.},
  author={T Kim and R A Mudry and C A Rexrode and Vinay K Pathak},
  journal={Journal of virology},
  year={1996},
  volume={70 11},
  pages={7594-602}
}
Retroviruses mutate at a high rate in vivo during viral replication. Mutations may occur during proviral transcription by RNA polymerase II, during minus-strand DNA synthesis (RNA template) by viral reverse transcriptase, or during plus-strand DNA synthesis (DNA template) by reverse transcriptase. To determine the contributions of different stages of replication to the retroviral mutation rates, we developed a spleen necrosis virus-based in vivo system to selectively identify mutations… CONTINUE READING

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