Retroviral-mediated transduction of the fanconi anemia C complementing (FACC) gene in two murine transplantation models.

Abstract

Fanconi anemia (FA) is a well-known genetic syndrome manifested by bone marrow failure, variable physical anomalies, and cancer susceptibility. This disorder is marked by genotypic and phenotypic heterogeneity and consists of four distinct complementation groups A, B, C, and D. The defective gene responsible for the C group of FA, FACC, was identified by… (More)

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