Retroviral infection of neonatal Peyer's patch lymphocytes: the mouse mammary tumor virus model.

Abstract

Mouse mammary tumor virus is known to infect newborn mice via mother's milk. A proposed key step for viral spread to the mammary gland is by the infection of lymphocytes. We show here that although in suckling mice retroviral proteins are found in all epithelial cells of the gut, viral DNA is exclusively detectable in the Peyer's patches. As early as 5 d after birth the infection leads to a superantigen response in the Peyer's patches but not in other lymphoid organs draining the intestine. Viral DNA can be detected before the superantigen response and becomes first evident in the Peyer's patches followed by mesenteric lymph nodes and finally all lymphoid organs.

Extracted Key Phrases

3 Figures and Tables

Statistics

050100'96'98'00'02'04'06'08'10'12'14'16
Citations per Year

328 Citations

Semantic Scholar estimates that this publication has 328 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Karapetian1994RetroviralIO, title={Retroviral infection of neonatal Peyer's patch lymphocytes: the mouse mammary tumor virus model.}, author={O. V. Karapetian and A. N. Shakhov and Jean-Pierre Kraehenbuhl and Hans Acha-Orbea}, journal={The Journal of experimental medicine}, year={1994}, volume={180 4}, pages={1511-6} }