Retroviral gene therapy with an immunoglobulin-antigen fusion construct protects from experimental autoimmune uveitis.

@article{Agarwal2000RetroviralGT,
  title={Retroviral gene therapy with an immunoglobulin-antigen fusion construct protects from experimental autoimmune uveitis.},
  author={Rajeev Kumar Agarwal and Yibin Kang and Elias T. Zambidis and David W. Scott and Chi Chao Chan and Rachel R Caspi},
  journal={The Journal of clinical investigation},
  year={2000},
  volume={106 2},
  pages={245-52}
}
Immunoglobulins can serve as tolerogenic carriers for antigens, and B cells can function as tolerogenic antigen-presenting cells. We used this principle to design a strategy for gene therapy of experimental autoimmune uveitis, a cell-mediated autoimmune disease model for human uveitis induced with the uveitogenic interphotoreceptor retinoid-binding protein… CONTINUE READING