Retroviral delivery of viral interleukin-10 into myeloid dendritic cells markedly inhibits their allostimulatory activity and promotes the induction of T-cell hyporesponsiveness.

@article{Takayama1998RetroviralDO,
  title={Retroviral delivery of viral interleukin-10 into myeloid dendritic cells markedly inhibits their allostimulatory activity and promotes the induction of T-cell hyporesponsiveness.},
  author={Takuya Takayama and Yasuhiko Nishioka and Li-na Lu and Michael T Lotze and Hideaki Tahara and Angus W Thomson},
  journal={Transplantation},
  year={1998},
  volume={66 12},
  pages={1567-74}
}
BACKGROUND Dendritic cells (DC) play critical roles in the initiation and modulation of immune responses and may determine the balance between tolerance and immunity. Viral interleukin-10 (vIL-10), encoded by the Epstein-Barr virus, is highly homologous to the "immunosuppressive" cytokine, mammalian IL-10. It impairs antigen-presenting cell function but lacks certain immunostimulatory properties of mammalian IL-10. We accomplished the following: (1) evaluated the effects of vIL-10 protein on DC… CONTINUE READING

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