Retroviral-based gene therapy with cyclooxygenase-2 promotes the union of bony callus tissues and accelerates fracture healing in the rat.

@article{Rundle2008RetroviralbasedGT,
  title={Retroviral-based gene therapy with cyclooxygenase-2 promotes the union of bony callus tissues and accelerates fracture healing in the rat.},
  author={Charles H. Rundle and Donna Dorough Strong and Shin-Tai Chen and Thomas A. Linkhart and Matilda H. C. Sheng and Jon E. Wergedal and K H William Lau and David J Prof Baylink},
  journal={The journal of gene medicine},
  year={2008},
  volume={10 3},
  pages={
          229-41
        }
}
BACKGROUND An in vivo gene therapy strategy was developed to accelerate bone fracture repair. METHODS Direct injection of a murine leukemia virus-based vector targeted transgene expression to the proliferating periosteal cells arising shortly after fracture. Cyclooxygenase-2 (Cox-2) was selected because the transgene for its prostaglandin products that promote angiogenesis, bone formation and bone resorption, are all required for fracture healing. The human (h) Cox-2 transgene was modified to… CONTINUE READING
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