Retroviral Scanning: Mapping MLV Integration Sites to Define Cell-specific Regulatory Regions.

Abstract

Moloney murine leukemia (MLV) virus-based retroviral vectors integrate predominantly in acetylated enhancers and promoters. For this reason, mLV integration sites can be used as functional markers of active regulatory elements. Here, we present a retroviral scanning tool, which allows the genome-wide identification of cell-specific enhancers and promoters… (More)
DOI: 10.3791/55919

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