Retrotransposons regulate host genes in mouse oocytes and preimplantation embryos.

  title={Retrotransposons regulate host genes in mouse oocytes and preimplantation embryos.},
  author={Anne E Peaston and Alexei V. Evsikov and Joel H. Graber and Wilhelmine N. de Vries and Andrea E Holbrook and Davor Solter and Barbara B Knowles},
  journal={Developmental cell},
  volume={7 4},
A comprehensive analysis of transposable element (TE) expression in mammalian full-grown oocytes reveals that LTR class III retrotransposons make an unexpectedly high contribution to the maternal mRNA pool, which persists in cleavage stage embryos. The most abundant transcripts in the mouse oocyte are from the mouse transcript (MT) retrotransposon family, and expression of this and other TE families is developmentally regulated. Furthermore, TEs act as alternative promoters and first exons for… CONTINUE READING
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