Retrotransposons Revisited: The Restraint and Rehabilitation of Parasites

@article{Goodier2008RetrotransposonsRT,
  title={Retrotransposons Revisited: The Restraint and Rehabilitation of Parasites},
  author={J. Goodier and H. Kazazian},
  journal={Cell},
  year={2008},
  volume={135},
  pages={23-35}
}
Retrotransposons, mainly LINEs, SINEs, and endogenous retroviruses, make up roughly 40% of the mammalian genome and have played an important role in genome evolution. Their prevalence in genomes reflects a delicate balance between their further expansion and the restraint imposed by the host. In any human genome only a small number of LINE1s (L1s) are active, moving their own and SINE sequences into new genomic locations and occasionally causing disease. Recent insights and new technologies… Expand
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