Retrotransposons Revisited: The Restraint and Rehabilitation of Parasites
@article{Goodier2008RetrotransposonsRT, title={Retrotransposons Revisited: The Restraint and Rehabilitation of Parasites}, author={J. Goodier and H. Kazazian}, journal={Cell}, year={2008}, volume={135}, pages={23-35} }
Retrotransposons, mainly LINEs, SINEs, and endogenous retroviruses, make up roughly 40% of the mammalian genome and have played an important role in genome evolution. Their prevalence in genomes reflects a delicate balance between their further expansion and the restraint imposed by the host. In any human genome only a small number of LINE1s (L1s) are active, moving their own and SINE sequences into new genomic locations and occasionally causing disease. Recent insights and new technologies… Expand
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