Retrotransposon insertions in the clonal evolution of pancreatic ductal adenocarcinoma

  title={Retrotransposon insertions in the clonal evolution of pancreatic ductal adenocarcinoma},
  author={Nemanja Rodi{\'c} and Jared Steranka and Alvin P. Makohon-Moore and Allison Moyer and Peilin Shen and Reema Sharma and Zachary A Kohutek and Cheng Ran Lisa Huang and Daniel Ahn and Paolo Mita and Martin S. Taylor and Norman J Barker and Ralph H. Hruban and Christine A Iacobuzio-Donahue and Jef D. Boeke and Kathleen H. Burns},
  journal={Nature Medicine},
Pancreatic ductal adenocarcinoma (PDAC) is typically diagnosed after the disease has metastasized; it is among the most lethal forms of cancer. We recently described aberrant expression of an open reading frame 1 protein, ORF1p, encoded by long interspersed element-1 (LINE-1; L1) retrotransposon, in PDAC. To test whether LINE-1 expression leads to somatic insertions of this mobile DNA, we used a targeted method to sequence LINE-1 insertion sites in matched PDAC and normal samples. We found… CONTINUE READING
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