Retrotransposon gag-like 1 (RTL1) and the molecular evolution of self-targeting imprinted microRNAs

  title={Retrotransposon gag-like 1 (RTL1) and the molecular evolution of self-targeting imprinted microRNAs},
  author={Avantika Mainieri and David Haig},
  journal={Biology Direct},
BackgroundTranscription of the antisense strand of RTL1 produces a sense mRNA that is targeted for degradation by antisense microRNAs transcribed from the sense strand. Translation of the mRNA produces a retrotransposon-derived protein that is implicated in placental development. The sense and antisense transcripts are oppositely imprinted: sense mRNAs are expressed from the paternally-derived chromosome, antisense microRNAs from the maternally-derived chromosome.ResultsTwo microRNAs at the… 

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