Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALS

@inproceedings{Krug2017RetrotransposonAC,
  title={Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALS},
  author={Lisa Krug and Nabanita Chatterjee and Rebeca Borges-Monroy and Stephen A Hearn and Wen-Wei Liao and Kathleen Morrill and Lisa Prazak and Nikolay V. Rozhkov and Delphine Theodorou and Molly C. Hammell and Josh Dubnau},
  booktitle={PLoS genetics},
  year={2017}
}
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are two incurable neurodegenerative disorders that exist on a symptomological spectrum and share both genetic underpinnings and pathophysiological hallmarks. Functional abnormality of TAR DNA-binding protein 43 (TDP-43), an aggregation-prone RNA and DNA binding protein, is observed in the vast majority of both familial and sporadic ALS cases and in ~40% of FTLD cases, but the cascade of events leading to cell death… CONTINUE READING