Retrotransposon Capture Sequencing (RC-Seq): A Targeted, High-Throughput Approach to Resolve Somatic L1 Retrotransposition in Humans.

@article{SnchezLuque2016RetrotransposonCS,
  title={Retrotransposon Capture Sequencing (RC-Seq): A Targeted, High-Throughput Approach to Resolve Somatic L1 Retrotransposition in Humans.},
  author={Francisco Jos{\'e} S{\'a}nchez-Luque and Sandra R. Richardson and Geoffrey J. Faulkner},
  journal={Methods in molecular biology},
  year={2016},
  volume={1400},
  pages={47-77}
}
Mobile genetic elements (MGEs) are of critical importance in genomics and developmental biology. Polymorphic and somatic MGE insertions have the potential to impact the phenotype of an individual, depending on their genomic locations and functional consequences. However, the identification of polymorphic and somatic insertions among the plethora of copies residing in the genome presents a formidable technical challenge. Whole genome sequencing has the potential to address this problem; however… CONTINUE READING
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