Retrotransposition and mutation events yield Rap1 GTPases with differential signalling capacity

@inproceedings{Zemojtel2010RetrotranspositionAM,
  title={Retrotransposition and mutation events yield Rap1 GTPases with differential signalling capacity},
  author={Tomasz Zemojtel and Marlena Duchniewicz and Zhongchun Zhang and Taisa Paluch and Hannes Luz and Tobias Penzkofer and J{\"u}rgen S. Scheele and Fried Jt Zwartkruis},
  booktitle={BMC Evolutionary Biology},
  year={2010}
}
Retrotransposition of mRNA transcripts gives occasionally rise to functional retrogenes. Through acquiring tempero-spatial expression patterns distinct from their parental genes and/or functional mutations in their coding sequences, such retrogenes may in principle reshape signalling networks. Here we present evidence for such a scenario, involving retrogenes of Rap1 belonging to the Ras family of small GTPases. We identified two murine and one human-specific retrogene of Rap1A and Rap1B, which… CONTINUE READING
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