Retrosynthetic design of heterologous pathways.

  title={Retrosynthetic design of heterologous pathways.},
  author={Pablo Carbonell and Anne-Ga{\"e}lle Planson and Jean-Loup Faulon},
  journal={Methods in molecular biology},
Tools from metabolic engineering and synthetic biology are synergistically used in order to develop high-performance cell factories. However, the number of successful applications has been limited due to the complexity of exploring efficiently the metabolic space for the discovery of candidate heterologous pathways. To address this challenge, retrosynthetic biology provides an integrated framework to formalize and rationalize the problem of importing biosynthetic pathways into a chassis… CONTINUE READING
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