Retrospective nationwide survey of Japanese patients with transfusion-dependent MDS and aplastic anemia highlights the negative impact of iron overload on morbidity/mortality.

@article{Takatoku2007RetrospectiveNS,
  title={Retrospective nationwide survey of Japanese patients with transfusion-dependent MDS and aplastic anemia highlights the negative impact of iron overload on morbidity/mortality.},
  author={Masaaki Takatoku and Takashi Uchiyama and Shinichiro Okamoto and Yuzuru Kanakura and Kenichi Sawada and Masao Tomonaga and Shinji Nakao and Tatsutoshi Nakahata and M. D. N. Harada and Takashi Murate and Keiya Ozawa},
  journal={European journal of haematology},
  year={2007},
  volume={78 6},
  pages={487-94}
}
OBJECTIVE Myelodysplastic syndromes (MDS) and aplastic anemia (AA) are the most common anemias that require transfusion therapy in Japan. This retrospective survey investigated relationships between iron overload, chelation practices, and morbidity/mortality in patients with these diseases. METHOD Medical histories of transfusion-dependent patients were assessed at transfusion onset, chelation onset, and study end. RESULTS Data were collected from 292 patients with MDS, AA, pure red cell… CONTINUE READING