Retrospective cohort study of methotrexate use in the treatment of pediatric Crohn's disease.

  title={Retrospective cohort study of methotrexate use in the treatment of pediatric Crohn's disease.},
  author={Whitney M. Sunseri and Jeffrey S. Hyams and Trudy J Lerer and D. Russell Mack and Anne Marie Griffiths and Anthony R Otley and Joel R. Rosh and Ryan S. Carvalho and Andrew B Grossman and Jos{\'e} Mar{\'i}a Cabrera and Marian Del Rosario Pfefferkorn and James N Rick and Neal S LeLeiko and Meredith C Hitch and Maria M Oliva-Hemker and Shehzad Ahmed Saeed and Michael D. Kappelman and James F Markowitz and David J. Keljo},
  journal={Inflammatory bowel diseases},
  volume={20 8},
BACKGROUND Methotrexate (MTX) use as an alternative to thiopurines in the treatment of Crohn's disease (CD) in children is increasing. This study was undertaken to assess safety and efficacy of MTX in children with CD. METHODS Patients treated with MTX with a minimum of 1-year follow-up were identified in the Pediatric IBD Collaborative Research Group Registry, a prospective inception cohort study started in 2002. The clinical efficacy and safety of MTX were analyzed retrospectively… CONTINUE READING
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