Retrospective Study of Outcomes in Hyalgan®-Treated Patients with Osteoarthritis of the Knee

@article{Barrett2002RetrospectiveSO,
  title={Retrospective Study of Outcomes in Hyalgan{\textregistered}-Treated Patients with Osteoarthritis of the Knee},
  author={John P Barrett and Paola Siviero},
  journal={Clinical Drug Investigation},
  year={2002},
  volume={22},
  pages={87-97}
}
AbstractObjective: To evaluate therapeutic success [defined as lack of total knee replacement surgery (TKR) or other significant clinical intervention during a 6-month follow-up] and to identify baseline patient and disease characteristics associated with improved pain relief and quality of life (QOL) in patients in a clinical practice who were treated with a single course of Hyalgan® (intra-articular hyaluronan) for pain associated with osteoarthritis (OA) of the knee. Design and setting… 

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References

SHOWING 1-10 OF 18 REFERENCES

Intra-articular Hyaluronic acid in the treatment of osteoarthritis of the knee: a long term study

The efficacy and tolerability of repeated courses of treatment with hyaluronic acid in patients with osteoarthritis of the knee was judged as «very good» in 36 cases, «good» in 30 cases, and «poor» in 9 cases.

Intra-articular hyaluronic acid: duration of effect and results of repeated treatment cycles.

Analysis of pain according to a visual analog scale showed significant improvements lasting 12 months, with pain during load, pain at rest, and duration of walking ability compared with a baseline evaluation, and significant improvements were also seen in knee function and in global evaluations by both patient and investigators.

Hyaluronic acid in the treatment of osteoarthritis of the knee.

The study demonstrated that five weekly intra-articular injections of sodium hyaluronate (Hyalgan) were superior to placebo and well tolerated in patients with osteoarthritis of the knee with a symptomatic benefit which persisted for 6 months.

Intraarticular sodium hyaluronate (Hyalgan) in the treatment of patients with osteoarthritis of the knee: a randomized clinical trial. Hyalgan Study Group.

This large, controlled randomized clinical trial confirms that 5 weekly IA injections of HA (Hyalgan) in patients with OA of the knee are generally well tolerated, provide sustained relief of pain and improved patient function, and were at least as effective with fewer adverse reactions as continuous treatment with naproxen for 26 weeks.

Viscosupplementation with hylan for the treatment of osteoarthritis: findings from clinical practice in Canada.

Hylan G-F 20 provided good clinical benefits and an acceptable safety profile in current clinical practice and the occurrence of adverse events after an intraarticular hylan injection is infrequent and unpredictable and is not necessarily hylan related, although injection related.

The safety and efficacy of different dose schedules of hyaluronic acid in the treatment of painful osteoarthritis of the knee with joint effusion

Long-term monitoring of the patients, over a period of six months, provided evidence of the value of repeater injections of HA in terms of maintenance of the results.

Intra-articular injections of 750 kD hyaluronan in the treatment of osteoarthritis: a randomised single centre double-blind placebo-controlled trial of 91 patients demonstrating lack of efficacy.

It is concluded that intraarticular administration of this preparation of 750 kD hyaluronan offers no significant benefit over placebo during a five week treatment period, but incurs a significantly higher morbidity, and therefore has no place in the routine treatment of osteoarthritis.

Correlation of roentgenographic patterns and clinical manifestations of symptomatic idiopathic osteoarthritis of the knee.

A classification system of IOA that has been designed and modified to reflect the unique roentgenographic, epidemiologic, and clinical characterization of the six subsets of tibiofemoral deformity is reported on.

Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association.

Variables from the medical history, physical examination, laboratory tests, and radiographs were used to develop sets of criteria that serve different investigative purposes and these proposed criteria utilize classification trees, or algorithms.