Retrospective Study of Outcomes in Hyalgan®-Treated Patients with Osteoarthritis of the Knee

@article{Barrett2002RetrospectiveSO,
  title={Retrospective Study of Outcomes in Hyalgan{\textregistered}-Treated Patients with Osteoarthritis of the Knee},
  author={John P Barrett and Paola Siviero},
  journal={Clinical Drug Investigation},
  year={2002},
  volume={22},
  pages={87-97}
}
AbstractObjective: To evaluate therapeutic success [defined as lack of total knee replacement surgery (TKR) or other significant clinical intervention during a 6-month follow-up] and to identify baseline patient and disease characteristics associated with improved pain relief and quality of life (QOL) in patients in a clinical practice who were treated with a single course of Hyalgan® (intra-articular hyaluronan) for pain associated with osteoarthritis (OA) of the knee. Design and setting… 
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TLDR
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Long-term effect of sodium hyaluronate (Hyalgan) on osteoarthritis progression in a rabbit model.
BACKGROUND Intra-articular (IA) hyaluronan (HA) injections are approved for the treatment of knee osteoarthritis (OA) pain. One of the currently available products is approved for repeat treatment
Hyaluronans in the treatment of osteoarthritis of the knee: evidence for disease-modifying activity.
TLDR
Growing preclinical and clinical evidence supports the notion that, in addition to relieving the symptoms of OA, HAs also modify the structure of the diseased joint and the rate ofOA disease progression, at least early in the evolution of the disease process.
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