Retroperitoneal inoculation of murine neuroblastoma results in a reliable model for evaluation of the antitumor immune response.

@article{Katsanis1994RetroperitonealIO,
  title={Retroperitoneal inoculation of murine neuroblastoma results in a reliable model for evaluation of the antitumor immune response.},
  author={Emmanuel Katsanis and Bruce R Blazar and Mar{\'i}a A. Bausero and Roland Gunther and Peter A.M. Anderson},
  journal={Journal of pediatric surgery},
  year={1994},
  volume={29 4},
  pages={538-42}
}
To more closely mimic the natural site of human neuroblastoma and the original spontaneous arising paraspinal murine tumor, the authors developed a new model system in which murine neuroblastoma cells (neuro-2a) are implanted directly into the retroperitoneal space. This method of administration resulted in an aggressive and reproducible neuroblastoma model, with death occurring at a median of 20.3 days after tumor implantation using 1 x 10(6) neuro-2a cells, compared with the intraperitoneal… CONTINUE READING

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