Retromer and Rab2-dependent trafficking mediate PS1 degradation by proteasomes in endocytic disturbance.

@article{Ueda2016RetromerAR,
  title={Retromer and Rab2-dependent trafficking mediate PS1 degradation by proteasomes in endocytic disturbance.},
  author={Naoya Ueda and Taisuke Tomita and Katsuhiko Yanagisawa and Nobuyuki Kimura},
  journal={Journal of neurochemistry},
  year={2016},
  volume={137 4},
  pages={647-58}
}
Accumulating evidence suggests that endocytic pathway deficits are involved in Alzheimer's disease pathogenesis. Several reports show that endocytic disturbance affects β-amyloid peptide (Aβ) cleavage from β-amyloid precursor protein (APP). Presenilin-1 (PS1) is the catalytic core of the γ-secretase complex required for Aβ generation. Previously, we showed that aging induces endocytic disturbance, resulting in the accumulation of Aβ and APP in enlarged endosomes. It remains unclear, however… CONTINUE READING
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