Retrograde transport of transmissible mink encephalopathy within descending motor tracts.

@article{Bartz2002RetrogradeTO,
  title={Retrograde transport of transmissible mink encephalopathy within descending motor tracts.},
  author={Jason C Bartz and A E Kincaid and Richard A. Bessen},
  journal={Journal of virology},
  year={2002},
  volume={76 11},
  pages={5759-68}
}
The spread of the abnormal conformation of the prion protein, PrP(Sc), within the spinal cord is central to the pathogenesis of transmissible prion diseases, but the mechanism of transport has not been determined. For this report, the route of transport of the HY strain of transmissible mink encephalopathy (TME), a prion disease of mink, in the central nervous system following unilateral inoculation into the sciatic nerves of Syrian hamsters was investigated. PrP(Sc) was detected at 3 weeks… CONTINUE READING

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