Retrograde transport of neurotrophins: fact and function.

@article{Campenot2004RetrogradeTO,
  title={Retrograde transport of neurotrophins: fact and function.},
  author={Robert B. Campenot and Bronwyn L Macinnis},
  journal={Journal of neurobiology},
  year={2004},
  volume={58 2},
  pages={217-29}
}
Retrograde signals generated by nerve growth factor (NGF) and other neurotrophins promote the survival of appropriately connected neurons during development, and failure to obtain sufficient retrograde signals may contribute to neuronal death occurring in many neurodegenerative diseases. The discovery over 25 years ago that NGF supplied to the axon terminals is retrogradely transported to the cell bodies suggested that NGF must reach the cell body to promote neuronal survival. Research during… CONTINUE READING
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