Retrograde transneuronal transfer of herpes simplex virus type 1 (HSV 1) from motoneurones.

@article{Ugolini1987RetrogradeTT,
  title={Retrograde transneuronal transfer of herpes simplex virus type 1 (HSV 1) from motoneurones.},
  author={Gabriella Ugolini and H. G. J. M. Kuypers and Anthony Simmons},
  journal={Brain research},
  year={1987},
  volume={422 2},
  pages={242-56}
}
The use of Herpes simplex virus (HSV) as a retrograde transneuronal tracer would have the unique advantage that the virus would be replicated in the second order neurones, resulting in strong labelling. HSV was injected in the XII nerve (mice). The virus was detected immunohistochemically. Four stages in the brainstem distribution of HSV-positive neurones were distinguished. These stages were correlated with injected amounts/survival time. In stage 1, positive neurones were restricted to the… CONTINUE READING

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