Retrograde transfer of replication deficient recombinant adenovirus vector in the central nervous system for tracing studies.

@article{Kuo1995RetrogradeTO,
  title={Retrograde transfer of replication deficient recombinant adenovirus vector in the central nervous system for tracing studies.},
  author={Helen P Kuo and Donald K. Ingram and R G Crystal and Andrea Mastrangeli},
  journal={Brain research},
  year={1995},
  volume={705 1-2},
  pages={31-8}
}
We assessed the application of a replication deficient recombinant adenovirus vector as a retrograde tracer in neural pathway studies. The adenovirus vector, Ad. RSV betagal, containing the intracellular marker gene, beta-galactosidase, was injected directly into the laterodorsal striatum of rats. The retrograde transport of the vector from the injection site was clearly visible in the cerebral cortex, thalamic nucleus, and substantia nigra. No evidence for anterograde transport of the vector… CONTINUE READING