Retrograde trafficking of AB5 toxins: mechanisms to therapeutics

  title={Retrograde trafficking of AB5 toxins: mechanisms to therapeutics},
  author={Somshuvra Mukhopadhyay and Adam D. Linstedt},
  journal={Journal of Molecular Medicine},
Bacterial AB5 toxins are a clinically relevant class of exotoxins that include several well-known members such as Shiga, cholera, and pertussis toxins. Infections with toxin-producing bacteria cause devastating human diseases that affect millions of individuals each year and have no definitive medical treatment. The molecular targets of AB5 toxins reside in the cytosol of infected cells, and the toxins reach the cytosol by trafficking through the retrograde membrane transport pathway that… CONTINUE READING

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