Retrograde signaling in the development and modification of synapses.

  title={Retrograde signaling in the development and modification of synapses.},
  author={Reiko Maki Fitzsimonds and Mu-Ming Poo},
  journal={Physiological reviews},
  volume={78 1},
Retrograde signaling from the postsynaptic cell to the presynaptic neuron is essential for the development, maintenance, and activity-dependent modification of synaptic connections. This review covers various forms of retrograde interactions at developing and mature synapses. First, we discuss evidence for early retrograde inductive events during synaptogenesis and how maturation of presynaptic structure and function is affected by signals from the postsynaptic cell. Second, we review the… 

Retrograde signaling at central synapses

  • H. TaoM. Poo
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 2001
Recent progress is reviewed in the understanding of the retrograde signaling at developing central synapses, where retrograde factors produced in association with activity-dependent synaptic plasticity are of particular interest.

Transsynaptic Regulation of Presynaptic Release Machinery in Central Synapses by Cell Adhesion Molecules

This review focuses on the postsynaptic mechanisms that retrogradely regulate presynaptic functionality and structure, emphasizing the role of neuronal adhesion molecules.

Review: Developmental Changes in Ionotropic Glutamate Receptors: Lessons from Hippocampal Synapses

Glutamatergic synapses are the primary source of excitatory transmission in the central nervous system (CNS), and their formation is critical in the establishment of neuronal connections. The

Differential signaling in presynaptic neurotransmitter release

Abstract.Neuronal communication is tightly regulated by presynaptic signaling, thereby temporarily and locally secreting one or more transmitters in order to exert propagation or modulation of

Stability and Plasticity of Developing Synapses in Hippocampal Neuronal Cultures

FM 1–43 fluorescence imaging observations provide new information on the stability of developing presynaptic function and suggest that NMDA receptor activation may regulate the Stability of developing synapses.



Spread of Synaptic Depression Mediated by Presynaptic Cytoplasmic Signaling

At developing neuromuscular synapses in Xenopus nerve-muscle cultures, a brief increase in the cytosolic calcium ion concentration in postsynaptic myocytes induced persistent depression of presynaptic transmitter secretion, which spread to distant synapses formed by the same neuron.

Interactions between nerve and muscle: synapse elimination at the developing neuromuscular junction.

In this review, the potential role that some of the factors involved in synapse formation might play in the less-well-understood phenomenon of synapse elimination is examined.

Retrograde signaling and the development of transmitter release properties in the invertebrate nervous system.

In organisms ranging from cats to crickets, evidence suggests that retrograde signaling is essential for matching these presynaptic release properties to individual postsynaptic partners.

Nitric oxide mediates activity-dependent synaptic suppression at developing neuromuscular synapses

Evidence is provided that nitric oxide (NO), a free radical implicated in several forms of synaptic plasticity, may serve as a retrograde signal for activity-dependent suppression in the neuromuscular synapse and may be triggered by NO released from a postsynaptic myocyte that fires asynchronously to the presynaptic terminal.

Proteolytic activity, synapse elimination, and the Hebb synapse.

Evidence is presented that proteases and protease inhibitors may be involved in modification of synaptic strength, and the protease/inhibitor model suggests additional specific mechanistic features for activity-dependent plasticity.

Role of intercellular interactions in heterosynaptic long-term depression

It is reported that in the CA1 region of the hippocampus this heterosynaptic long-term depression has the property that its sites of induction and expression occur in different populations of cells and thus requires the spread of a signal between neurons.

Dynamics of nerve-muscle interaction in developing and mature neuromuscular junctions.

Recent advances in understanding of the regulatory and inductive interactions involved in motor axon pathfinding, target recognition, bidirectional control of gene expression during synapse formation, motoneuron cell death, terminal rearrangement, and the ongoing remodeling of synaptic number, structure, and function are reviewed.