Retrograde signaling in injured nerve--the axon reaction revisited.

  title={Retrograde signaling in injured nerve--the axon reaction revisited.},
  author={Shlomit Hanz and Mike Fainzilber},
  journal={Journal of neurochemistry},
  volume={99 1},
Injury to axons elicits changes in macromolecule synthesis in the corresponding cell bodies that are critical for an effective regenerative response. For decades the most easily studied aspect of this phenomenon was the onset of chromatolysis, a suite of structural changes in the cell body characterized by swelling, shifting of the nucleus and dispersal of Nissl bodies. The question: 'what is the signal for chromatolysis?' received no less than 10 possible answers in a comprehensive review… CONTINUE READING
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