Retrograde signaling changes the venue of postsynaptic inhibition in rat substantia nigra.

@article{Yanovsky2003RetrogradeSC,
  title={Retrograde signaling changes the venue of postsynaptic inhibition in rat substantia nigra.},
  author={Yevgenij Yanovsky and S Mades and Ulrich Misgeld},
  journal={Neuroscience},
  year={2003},
  volume={122 2},
  pages={317-28}
}
Both endocannabinoids through cannabinoid receptor type I (CB1) receptors and dopamine through dopamine receptor type D1 receptors modulate postsynaptic inhibition in substantia nigra by changing GABA release from striatonigral terminals. By recording from visually identified pars compacta and pars reticulata neurons we searched for a possible co-release and interaction of endocannabinoids and dopamine. Depolarization of a neuron in pars reticulata or in pars compacta transiently suppressed… CONTINUE READING

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