Retrograde regulation of synaptic vesicle endocytosis and recycling

  title={Retrograde regulation of synaptic vesicle endocytosis and recycling},
  author={Kristina D. Micheva and Joann Buchanan and Ronald W Holz and Stephen M Smith},
  journal={Nature Neuroscience},
Sustained release of neurotransmitter depends upon the recycling of synaptic vesicles. Until now, it has been assumed that vesicle recycling is regulated by signals from the presynaptic bouton alone, but results from rat hippocampal neurons reported here indicate that this need not be the case. Fluorescence imaging and pharmacological analysis show that a nitric oxide (NO) signal generated postsynaptically can regulate endocytosis and at least one later step in synaptic vesicle recycling. The… CONTINUE READING


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A presynaptic inositol5phosphatase

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