Retrograde propagation of GDNF-mediated signals in sympathetic neurons.

  title={Retrograde propagation of GDNF-mediated signals in sympathetic neurons.},
  author={Muriel Coulpier and Carlos F. Ib{\'a}{\~n}ez},
  journal={Molecular and cellular neurosciences},
  volume={27 2},
Glial cell line-derived neurotrophic factor (GDNF) family ligands are target-derived trophic factors for several neuronal subpopulations. They promote survival and neurite outgrowth through binding to specific members of the GDNF family receptor alpha (GFR alpha) and subsequent activation of the RET tyrosine kinase receptor. Using compartmentalized cultures of sympathetic neurons, we have studied the mechanism of GDNF retrograde signaling. Our results demonstrate the presence of GDNF receptors… CONTINUE READING