Retrograde perfusion with a sodium channel antagonist provides ischemic spinal cord protection.

@article{Gangemi2000RetrogradePW,
  title={Retrograde perfusion with a sodium channel antagonist provides ischemic spinal cord protection.},
  author={James J. Gangemi and John A. Kern and S. D. Ross and Kim S Shockey and Irving L. Kron and Curtis G. Tribble},
  journal={The Annals of thoracic surgery},
  year={2000},
  volume={69 6},
  pages={1744-8; discussion 1748-9}
}
BACKGROUND Neuronal voltage-dependent sodium channel antagonists have been shown to provide neuroprotection in focal and global cerebral ischemic models. We hypothesized that retrograde spinal cord venous perfusion with phenytoin, a neuronal voltage-dependent sodium channel antagonist, would provide protection during prolonged spinal cord ischemia. METHODS In a rabbit model, spinal cord ischemia was induced for 45 minutes. Six groups of animals were studied. Controls (group I, n = 8) received… CONTINUE READING