Retrograde nuclear transport from the cytoplasm is required for tRNATyr maturation in T. brucei

  title={Retrograde nuclear transport from the cytoplasm is required for tRNATyr maturation in T. brucei},
  author={Alan C. Kessler and Sneha Kulkarni and Mellie June Paulines and Mary Anne T. Rubio and Patrick A. Limbach and Zdeněk Paris and Juan D. Alfonzo},
  journal={RNA Biology},
  pages={528 - 536}
ABSTRACT Retrograde transport of tRNAs from the cytoplasm to the nucleus was first described in Saccharomyces cerevisiae and most recently in mammalian systems. Although the function of retrograde transport is not completely clear, it plays a role in the cellular response to changes in nutrient availability. Under low nutrient conditions tRNAs are sent from the cytoplasm to nucleus and presumably remain in storage there until nutrient levels improve. However, in S. cerevisiae tRNA retrograde… 

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