Retrograde neural circuit specification by target-derived neurotrophins and growth factors.

@article{Silva2011RetrogradeNC,
  title={Retrograde neural circuit specification by target-derived neurotrophins and growth factors.},
  author={Susana da Silva and Fan Wang},
  journal={Current opinion in neurobiology},
  year={2011},
  volume={21 1},
  pages={61-7}
}
Neural circuit assembly during development involves a series of highly regulated steps. While genetically pre-determined programs play key roles in the early steps including neurogenesis, migration, and initial growth and guidance of axons; increasing evidence indicates that as the axons reach their targets, the late steps of neuronal differentiation and connectivity formation may be influenced or even specified by target-derived signals. Here we attempt to provide a brief synthesized review on… CONTINUE READING
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