Retrograde flow and shear rate acutely impair endothelial function in humans.

  title={Retrograde flow and shear rate acutely impair endothelial function in humans.},
  author={Dick H J Thijssen and Ellen Adele Dawson and Toni Marie Tinken and Nigel Timothy Cable and Daniel John Green},
  volume={53 6},
Changes in arterial shear stress induce functional and structural vasculature adaptations. Recent studies indicate that substantial retrograde flow and shear can occur through human conduit arteries. In animals, retrograde shear is associated with atherogenic effects. The aim of this study was to examine the impact of incremental levels of retrograde shear on endothelial function in vivo. On 3 separate days, we examined bilateral brachial artery flow-mediated dilation, an index of NO-mediated… CONTINUE READING
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