Retrograde delivery of photosensitizer (TPPp-O-beta-GluOH)3 selectively potentiates its photodynamic activity.

@article{Amessou2008RetrogradeDO,
  title={Retrograde delivery of photosensitizer (TPPp-O-beta-GluOH)3 selectively potentiates its photodynamic activity.},
  author={Mohamed Amessou and Dani{\`e}le Carrez and Delphine Patin and Marianne Sarr and David S Grierson and Alain Croisy and Ant{\^o}nio Cl{\'a}udio Tedesco and Philippe Maillard and Ludger Johannes},
  journal={Bioconjugate chemistry},
  year={2008},
  volume={19 2},
  pages={532-8}
}
Photodynamic therapy involves administration of a photosensitizing drug and its subsequent activation by visible light of the appropriate wavelength. Several approaches to increasing the specificity of photosensitizers for cancerous tissues and, in particular, through their conjugation to ligands that are directed against tumor-associated antigens have been investigated. Here, we have studied the delivery of the photocytotoxic porphyrin compound TPP(p-O-beta-D-GluOH)3 into tumor cells that… CONTINUE READING