Retrograde axonal transport and motor neuron disease.

  title={Retrograde axonal transport and motor neuron disease.},
  author={Anna-Lena Str{\"o}m and J{\'o}zsef G{\'a}l and Ping Shi and Edward J. Kasarskis and Lawrence J. Hayward and Haining Zhu},
  journal={Journal of neurochemistry},
  volume={106 2},
Transport of material between extensive neuronal processes and the cell body is crucial for neuronal function and survival. Growing evidence shows that deficits in axonal transport contribute to the pathogenesis of multiple neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Here we review recent data indicating that defects in dynein-mediated retrograde axonal transport are involved in ALS etiology. We discuss how mutant copper-zinc superoxide dismutase (SOD1) and an… CONTINUE READING

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