Retrograde amnesia after hippocampal damage: Recent vs. remote memories in two tasks

@article{Sutherland2001RetrogradeAA,
  title={Retrograde amnesia after hippocampal damage: Recent vs. remote memories in two tasks},
  author={Robert J Sutherland and Michael P. Weisend and Dave G. Mumby and Robert S. Astur and Faith M. Hanlon and Amy Koerner and Michael J. Thomas and Ying Wu and Sandra N. Moses and Carrie Cole and Derek A Hamilton and Janice M. Hoesing},
  journal={Hippocampus},
  year={2001},
  volume={11}
}
We review evidence from experiments conducted in our laboratory on retrograde amnesia in rats with damage to the hippocampal formation. In a new experiment reported here, we show that N‐methyl‐D‐aspartate (NMDA)‐induced hippocampal damage produced retrograde amnesia for both hidden platform and two‐choice visible platform discriminations in the Morris water task. For both problems there was a significant trend for longer training‐surgery intervals to be associated with worse retention… 
Hippocampal lesions produce both nongraded and temporally graded retrograde amnesia in the same rat
Rats were administered contextual fear conditioning and trained on a water‐maze, spatial memory task 28 days or 24 h before undergoing hippocampal lesion or control surgery. When tested
Hippocampal area CA1 and remote memory in rats.
TLDR
A discrete lesion targeting area CA1, the sole output of the hippocampus to neocortex, was developed and tested the effects of this lesion on recent and remote memory in the watermaze task, in context fear conditioning, and in trace fear conditioning; in all three tasks, recent andRemote memory were similarly impaired after CA1 lesions.
Hippocampal damage produces retrograde but not anterograde amnesia for a cued location in a spontaneous exploratory task in rats
TLDR
A role for the hippocampus in the retention of spatial memory acquired during exploration is confirmed and the absence of anterograde impairment vs. the presence of retrograde impairment for memory of a spatial home base is confirmed.
Anterograde Amnesia and Temporally Graded Retrograde Amnesia for a Nonspatial Memory Task after Lesions of Hippocampus and Subiculum
TLDR
The results show the importance of the hippocampus and related structures for nonspatial memory and also demonstrate the temporary role of these structures in long-term memory.
Growth points in research on memory and hippocampus.
TLDR
It is shown in many memory tasks that complete damage to the hippocampus produces retrograde amnesia that is equivalent for recent and remote memories.
Heterarchic reinstatement of long-term memory: A concept on hippocampal amnesia in rodent memory research
Hippocampus and remote spatial memory in rats
Damage to the hippocampus typically produces temporally graded retrograde amnesia, whereby memories acquired recently are impaired more than memories acquired remotely. This phenomenon has been
Retrograde amnesia for visual memories after hippocampal damage in rats.
TLDR
It is proposed that, although simple discrimination learning may proceed in the absence of the hippocampus, it plays an important role in this type of learning when it is intact, and retrograde amnesia for simple picture discriminations is severe if such discriminations are first learned while the hippocampus is intact.
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